diff --git a/var/spack/repos/builtin/packages/py-amrex/package.py b/var/spack/repos/builtin/packages/py-amrex/package.py
index 61f8aeadd0..a282b2095c 100644
--- a/var/spack/repos/builtin/packages/py-amrex/package.py
+++ b/var/spack/repos/builtin/packages/py-amrex/package.py
@@ -87,7 +87,7 @@ def setup_build_environment(self, env):
 
         # disable superbuilds: use external dependencies
         env.set("AMREX_INTERNAL", "OFF")
-        env.set("PYAMREX_CCACHE", "ON")
+        env.set("PYAMREX_CCACHE", "OFF")
         env.set("PYAMREX_IPO", "ON")
         env.set("PYBIND11_INTERNAL", "OFF")