diff --git a/var/spack/repos/builtin/packages/py-fastfold/package.py b/var/spack/repos/builtin/packages/py-fastfold/package.py
new file mode 100644
index 0000000000..d5752a2eaa
--- /dev/null
+++ b/var/spack/repos/builtin/packages/py-fastfold/package.py
@@ -0,0 +1,40 @@
+# Copyright 2013-2022 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack.package import *
+
+
+class PyFastfold(PythonPackage):
+    """Optimizing Protein Structure Prediction Model Training and Inference on
+    GPU Clusters."""
+
+    homepage = "https://github.com/hpcaitech/FastFold"
+    url = "https://github.com/hpcaitech/FastFold/archive/refs/tags/0.2.0.tar.gz"
+
+    maintainers = ["meyersbs"]
+
+    version("0.2.0", sha256="6760dbae9809b8b26219c9477489d34325807be504098901d0375fbdc3103f88")
+
+    # From README:
+    depends_on("python@3.8:", type=("build", "run"))  # Req Relaxed (was @3.8:3.9)
+    depends_on("cuda@11.1:", type=("build", "run"))
+    depends_on("py-torch@1.10:+cuda", type=("build", "run"))
+    # From setup.py:
+    depends_on("py-setuptools", type="build")
+    depends_on("py-einops", type=("build", "run"))
+    depends_on("py-colossalai", type=("build", "run"))
+    # From environment.yml (to appease import errors):
+    depends_on("py-scipy@1.7.1:", type=("build", "run"))  # Req relaxed (was @1.7.1)
+    depends_on("py-dm-tree@0.1.6:", type=("build", "run"))  # Req relaxed (was @0.1.6)
+    depends_on("py-biopython@1.79:", type=("build", "run"))  # Req relaxed (was @1.79)
+    depends_on("py-ml-collections@0.1.0:", type=("build", "run"))  # Req relaxed (was @0.1.0)
+    depends_on("py-ray@2.0.0:", type=("build", "run"))  # Req relaxed (was @2.0.0)
+    depends_on("py-pandas", type=("build", "run"))
+    depends_on("openmm@7.7.0:+cuda", type=("build", "run"))
+    depends_on("py-requests@2.26.0:", type=("build", "run"))  # Req relaxed (was @2.26.0)
+    # From import errors:
+    depends_on("py-setproctitle", type=("build", "run"))
+    depends_on("py-pdbfixer", type=("build", "run"))
+    depends_on("py-pytorch-lightning", type=("build", "run"))