diff --git a/var/spack/repos/builtin/packages/py-jaxlib/package.py b/var/spack/repos/builtin/packages/py-jaxlib/package.py
index d8def42008..b4c7daba27 100644
--- a/var/spack/repos/builtin/packages/py-jaxlib/package.py
+++ b/var/spack/repos/builtin/packages/py-jaxlib/package.py
@@ -47,6 +47,13 @@ class PyJaxlib(PythonPackage, CudaPackage):
     depends_on("py-absl-py", when="@:0.3", type=("build", "run"))
     depends_on("py-flatbuffers@1.12:2", when="@0.1", type=("build", "run"))
 
+    conflicts(
+        "cuda_arch=none",
+        when="+cuda",
+        msg="Must specify CUDA compute capabilities of your GPU, see "
+        "https://developer.nvidia.com/cuda-gpus",
+    )
+
     def patch(self):
         self.tmp_path = tempfile.mkdtemp(prefix="spack")
         self.buildtmp = tempfile.mkdtemp(prefix="spack")