diff --git a/var/spack/repos/builtin/packages/pblat/package.py b/var/spack/repos/builtin/packages/pblat/package.py
new file mode 100644
index 0000000000..b62a96eb2a
--- /dev/null
+++ b/var/spack/repos/builtin/packages/pblat/package.py
@@ -0,0 +1,30 @@
+# Copyright 2013-2024 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack.package import *
+
+
+class Pblat(MakefilePackage):
+    """Parallelized blat with multi-threads support"""
+
+    homepage = "http://icebert.github.io/pblat/"
+    url = "https://github.com/icebert/pblat/archive/refs/tags/2.5.1.tar.gz"
+
+    # `pblat` shares the license for Jim Kent's `blat`. For-profit users must visit:
+    license_url = "https://kentinformatics.com/"
+
+    version("2.5.1", sha256="e85a4d752b8e159502d529f0f9e47579851a6b466b6c2f1f4d49f598642bc615")
+
+    depends_on("openssl")
+    depends_on("zlib-api")
+
+    def edit(self, spec, prefix):
+        makefile = FileFilter("Makefile")
+        makefile.filter("MACHTYPE=x86_64", "MACHTYPE?=x86_64")
+        makefile.filter("CC=gcc", "")
+
+    def install(self, spec, prefix):
+        mkdirp(prefix.bin)
+        install("pblat", prefix.bin)