diff --git a/var/spack/repos/builtin/packages/dxt-explorer/package.py b/var/spack/repos/builtin/packages/dxt-explorer/package.py
index 4f7df14c18..90ef648183 100644
--- a/var/spack/repos/builtin/packages/dxt-explorer/package.py
+++ b/var/spack/repos/builtin/packages/dxt-explorer/package.py
@@ -26,5 +26,5 @@ class DxtExplorer(PythonPackage):
 
     depends_on("darshan-util", type=("run"))
 
-    depends_on("python@3.6:", type=("build", "run"))
+    depends_on("py-setuptools", type="build")
     depends_on("py-pandas", type=("build", "run"))
diff --git a/var/spack/repos/builtin/packages/py-gpaw/package.py b/var/spack/repos/builtin/packages/py-gpaw/package.py
index 0f5072e927..f6759fb279 100644
--- a/var/spack/repos/builtin/packages/py-gpaw/package.py
+++ b/var/spack/repos/builtin/packages/py-gpaw/package.py
@@ -35,7 +35,7 @@ class PyGpaw(PythonPackage):
     depends_on("py-ase@3.19.0:", type=("build", "run"), when="@20.1.0")
     depends_on("py-ase@3.20.1:", type=("build", "run"), when="@20.10.0")
     depends_on("py-ase@3.21.0:", type=("build", "run"), when="@21.1.0")
-    depends_on("py-numpy +blas +lapack", type=("build", "run"))
+    depends_on("py-numpy", type=("build", "run"))
     depends_on("py-scipy", type=("build", "run"))
     depends_on("libxc@3:4.3.4")
     depends_on("blas")
diff --git a/var/spack/repos/builtin/packages/py-numpy/package.py b/var/spack/repos/builtin/packages/py-numpy/package.py
index e5ffea879c..8ee118d98e 100644
--- a/var/spack/repos/builtin/packages/py-numpy/package.py
+++ b/var/spack/repos/builtin/packages/py-numpy/package.py
@@ -5,16 +5,13 @@
 
 import platform
 import subprocess
+from typing import Tuple
 
 from spack.package import *
 
 
 class PyNumpy(PythonPackage):
-    """NumPy is the fundamental package for scientific computing with Python.
-    It contains among other things: a powerful N-dimensional array object,
-    sophisticated (broadcasting) functions, tools for integrating C/C++ and
-    Fortran code, and useful linear algebra, Fourier transform, and random
-    number capabilities"""
+    """Fundamental package for array computing in Python."""
 
     homepage = "https://numpy.org/"
     pypi = "numpy/numpy-1.23.0.tar.gz"
@@ -23,6 +20,8 @@ class PyNumpy(PythonPackage):
     maintainers("adamjstewart", "rgommers")
 
     version("main", branch="main")
+    version("1.26.1", sha256="c8c6c72d4a9f831f328efb1312642a1cafafaa88981d9ab76368d50d07d93cbe")
+    version("1.26.0", sha256="f93fc78fe8bf15afe2b8d6b6499f1c73953169fad1e9a8dd086cdff3190e7fdf")
     version("1.25.2", sha256="fd608e19c8d7c55021dffd43bfe5492fab8cc105cc8986f813f8c3c048b38760")
     version("1.25.1", sha256="9a3a9f3a61480cc086117b426a8bd86869c213fc4072e606f01c4e4b66eb92bf")
     version("1.25.0", sha256="f1accae9a28dc3cda46a91de86acf69de0d1b5f4edd44a9b0c3ceb8036dfff19")
@@ -87,11 +86,8 @@ class PyNumpy(PythonPackage):
     version("1.14.6", sha256="1250edf6f6c43e1d7823f0967416bc18258bb271dc536298eb0ea00a9e45b80a")
     version("1.14.5", sha256="a4a433b3a264dbc9aa9c7c241e87c0358a503ea6394f8737df1683c7c9a102ac")
 
-    variant("blas", default=True, description="Build with BLAS support")
-    variant("lapack", default=True, description="Build with LAPACK support")
-
-    # Based on wheel availability on PyPI
-    depends_on("python@3.9:3.11", when="@1.25:", type=("build", "link", "run"))
+    depends_on("python@3.9:3.12", when="@1.26:", type=("build", "link", "run"))
+    depends_on("python@3.9:3.11", when="@1.25", type=("build", "link", "run"))
     depends_on("python@3.8:3.11", when="@1.23.2:1.24", type=("build", "link", "run"))
     depends_on("python@3.8:3.10", when="@1.22:1.23.1", type=("build", "link", "run"))
     depends_on("python@:3.10", when="@1.21.2:1.21", type=("build", "link", "run"))
@@ -99,19 +95,30 @@ class PyNumpy(PythonPackage):
     depends_on("python@:3.8", when="@1.17.3:1.19.2", type=("build", "link", "run"))
     depends_on("python@:3.7", when="@1.14.5:1.17.2", type=("build", "link", "run"))
 
+    depends_on("py-cython@0.29.34:3", when="@1.26:", type="build")
+    depends_on("py-cython@0.29.34:2", when="@1.25", type="build")
+    depends_on("py-cython@0.29.30:2", when="@1.22.4:1.24", type="build")
+    depends_on("py-cython@0.29.24:2", when="@1.21.2:1.22.3", type="build")
+    depends_on("py-cython@0.29.21:2", when="@1.19.1:1.21.1", type="build")
+    depends_on("py-cython@0.29.14:2", when="@1.18.1:1.19.0", type="build")
+    depends_on("py-cython@0.29.13:2", when="@1.18.0", type="build")
+    depends_on("py-pyproject-metadata@0.7.1:", when="@1.26:", type="build")
+    depends_on("py-tomli@1:", when="@1.26: ^python@:3.10", type="build")
+    depends_on("py-setuptools@60:", when="@1.26: ^python@3.12:", type="build")
     # https://github.com/spack/spack/pull/32078
-    depends_on("py-setuptools@:63", type=("build", "run"))
+    depends_on("py-setuptools@:63", when="@:1.25", type=("build", "run"))
     depends_on("py-setuptools@:59", when="@:1.22.1", type=("build", "run"))
-    # Check pyproject.toml for updates to the required cython version
-    depends_on("py-cython@0.29.34:2", when="@1.25:", type="build")
-    depends_on("py-cython@0.29.13:2", when="@1.18.0:", type="build")
-    depends_on("py-cython@0.29.14:2", when="@1.18.1:", type="build")
-    depends_on("py-cython@0.29.21:2", when="@1.19.1:", type="build")
-    depends_on("py-cython@0.29.24:2", when="@1.21.2:", type="build")
-    depends_on("py-cython@0.29.30:2", when="@1.22.4:", type="build")
-    depends_on("blas", when="+blas")
-    depends_on("lapack", when="+lapack")
+    depends_on("py-colorama", when="@1.26: platform=windows", type="build")
 
+    # Required to use --config-settings
+    depends_on("py-pip@23.1:", when="@1.26:", type="build")
+    # meson is vendored, ninja and pkgconfig are not
+    depends_on("ninja@1.8.2:", when="@1.26:", type="build")
+    depends_on("pkgconfig", when="@1.26:", type="build")
+    depends_on("blas")
+    depends_on("lapack")
+
+    # test_requirements.txt
     depends_on("py-nose@1.0.0:", when="@:1.14", type="test")
     depends_on("py-pytest", when="@1.15:", type="test")
     depends_on("py-hypothesis", when="@1.19:", type="test")
@@ -145,13 +152,21 @@ class PyNumpy(PythonPackage):
         when="@1.22.0:1.22.3",
     )
 
-    # version 1.21.0 runs into an infinit loop during printing
+    # meson.build
+    # https://docs.scipy.org/doc/scipy/dev/toolchain.html#compilers
+    conflicts("%gcc@:8.3", when="@1.26:", msg="NumPy requires GCC >= 8.4")
+    conflicts("%gcc@:4.7", msg="NumPy requires GCC >= 4.8")
+    conflicts(
+        "%msvc@:19.19",
+        when="@1.26:",
+        msg="NumPy requires at least vc142 (default with Visual Studio 2019) "
+        "when building with MSVC",
+    )
+
+    # version 1.21.0 runs into an infinite loop during printing
     # (e.g. print(numpy.ones(1000)) when compiled with gcc 11
     conflicts("%gcc@11:", when="@1.21.0")
 
-    # GCC 4.8 is the minimum version that works
-    conflicts("%gcc@:4.7", msg="GCC 4.8+ required")
-
     # NVHPC support added in https://github.com/numpy/numpy/pull/17344
     conflicts("%nvhpc", when="@:1.19")
 
@@ -159,6 +174,10 @@ class PyNumpy(PythonPackage):
     conflicts("%intel", when="@1.23.0:1.23.3")
     conflicts("%oneapi", when="@1.23.0:1.23.3")
 
+    @property
+    def archive_files(self):
+        return [join_path(self.stage.source_path, "build", "meson-logs", "meson-log.txt")]
+
     def url_for_version(self, version):
         url = "https://files.pythonhosted.org/packages/source/n/numpy/numpy-{}.{}"
         if version >= Version("1.23"):
@@ -193,16 +212,68 @@ def flag_handler(self, name, flags):
 
         return (flags, None, None)
 
-    @run_before("install")
-    def set_blas_lapack(self):
-        # https://numpy.org/devdocs/user/building.html
-        # https://github.com/numpy/numpy/blob/master/site.cfg.example
+    def blas_lapack_pkg_config(self) -> Tuple[str, str]:
+        """Convert library names to pkg-config names.
 
-        # Skip if no BLAS/LAPACK requested
+        Returns:
+            The names of the blas and lapack libs that pkg-config should search for.
+        """
         spec = self.spec
-        if "+blas" not in spec and "+lapack" not in spec:
-            return
+        blas = spec["blas"].libs.names[0]
+        lapack = spec["lapack"].libs.names[0]
 
+        if spec["blas"].name in ["intel-mkl", "intel-parallel-studio", "intel-oneapi-mkl"]:
+            blas = "mkl-dynamic-lp64-seq"
+
+        if spec["lapack"].name in ["intel-mkl", "intel-parallel-studio", "intel-oneapi-mkl"]:
+            lapack = "mkl-dynamic-lp64-seq"
+
+        if spec["blas"].name in ["blis", "amdblis"]:
+            blas = "blis"
+
+        if spec["blas"].name == "cray-libsci":
+            blas = "libsci"
+
+        if spec["lapack"].name == "cray-libsci":
+            lapack = "libsci"
+
+        if "armpl" in blas:
+            if "_mp" in blas:
+                blas = "armpl-dynamic-lp64-omp"
+            else:
+                blas = "armpl-dynamic-lp64-seq"
+
+        if "armpl" in lapack:
+            if "_mp" in lapack:
+                lapack = "armpl-dynamic-lp64-omp"
+            else:
+                lapack = "armpl-dynamic-lp64-seq"
+
+        return blas, lapack
+
+    @when("@1.26:")
+    def config_settings(self, spec, prefix):
+        blas, lapack = self.blas_lapack_pkg_config()
+        return {
+            "builddir": "build",
+            "compile-args": f"-j{make_jobs}",
+            "setup-args": {
+                # https://scipy.github.io/devdocs/building/blas_lapack.html
+                "-Dblas": blas,
+                "-Dlapack": lapack,
+                # https://numpy.org/doc/stable/reference/simd/build-options.html
+                # TODO: get this working in CI
+                # "-Dcpu-baseline": "native",
+                # "-Dcpu-dispatch": "none",
+            },
+        }
+
+    def blas_lapack_site_cfg(self) -> None:
+        """Write a site.cfg file to configure BLAS/LAPACK."""
+        spec = self.spec
+
+        # https://numpy.org/doc/1.25/user/building.html
+        # https://github.com/numpy/numpy/blob/v1.25.2/site.cfg.example
         def write_library_dirs(f, dirs):
             f.write("library_dirs = {0}\n".format(dirs))
             if not (
@@ -211,17 +282,11 @@ def write_library_dirs(f, dirs):
             ):
                 f.write("rpath = {0}\n".format(dirs))
 
-        blas_libs = LibraryList([])
-        blas_headers = HeaderList([])
-        if "+blas" in spec:
-            blas_libs = spec["blas"].libs
-            blas_headers = spec["blas"].headers
+        blas_libs = spec["blas"].libs
+        blas_headers = spec["blas"].headers
 
-        lapack_libs = LibraryList([])
-        lapack_headers = HeaderList([])
-        if "+lapack" in spec:
-            lapack_libs = spec["lapack"].libs
-            lapack_headers = spec["lapack"].headers
+        lapack_libs = spec["lapack"].libs
+        lapack_headers = spec["lapack"].headers
 
         lapackblas_libs = lapack_libs + blas_libs
         lapackblas_headers = lapack_headers + blas_headers
@@ -334,15 +399,25 @@ def write_library_dirs(f, dirs):
                     write_library_dirs(f, lapack_lib_dirs)
                     f.write("include_dirs = {0}\n".format(lapack_header_dirs))
 
+    @when("@:1.25")
+    @run_before("install")
+    def set_blas_lapack(self):
+        self.blas_lapack_site_cfg()
+
+    @when("@1.26:")
+    def setup_build_environment(self, env):
+        # https://github.com/scipy/scipy/issues/19357
+        if self.spec.satisfies("%apple-clang@15:"):
+            env.append_flags("LDFLAGS", "-Wl,-ld_classic")
+
+    @when("@:1.25")
     def setup_build_environment(self, env):
         # Tell numpy which BLAS/LAPACK libraries we want to use.
-        # https://github.com/numpy/numpy/pull/13132
-        # https://numpy.org/devdocs/user/building.html#accelerated-blas-lapack-libraries
         spec = self.spec
-        # https://numpy.org/devdocs/user/building.html#blas
-        if "blas" not in spec:
-            blas = ""
-        elif (
+        # https://github.com/numpy/numpy/pull/13132
+        # https://numpy.org/doc/1.25/user/building.html#accelerated-blas-lapack-libraries
+        # https://numpy.org/doc/1.25/user/building.html#blas
+        if (
             spec["blas"].name == "intel-mkl"
             or spec["blas"].name == "intel-parallel-studio"
             or spec["blas"].name == "intel-oneapi-mkl"
@@ -361,10 +436,8 @@ def setup_build_environment(self, env):
 
         env.set("NPY_BLAS_ORDER", blas)
 
-        # https://numpy.org/devdocs/user/building.html#lapack
-        if "lapack" not in spec:
-            lapack = ""
-        elif (
+        # https://numpy.org/doc/1.25/user/building.html#lapack
+        if (
             spec["lapack"].name == "intel-mkl"
             or spec["lapack"].name == "intel-parallel-studio"
             or spec["lapack"].name == "intel-oneapi-mkl"
diff --git a/var/spack/repos/builtin/packages/py-pip/package.py b/var/spack/repos/builtin/packages/py-pip/package.py
index 52d290d0b5..dfa85d55bc 100644
--- a/var/spack/repos/builtin/packages/py-pip/package.py
+++ b/var/spack/repos/builtin/packages/py-pip/package.py
@@ -15,6 +15,8 @@ class PyPip(Package, PythonExtension):
     url = "https://files.pythonhosted.org/packages/py3/p/pip/pip-20.2-py3-none-any.whl"
     list_url = "https://pypi.org/simple/pip/"
 
+    tags = ["build-tools"]
+
     maintainers("adamjstewart", "pradyunsg")
 
     version(
diff --git a/var/spack/repos/builtin/packages/py-pyfr/package.py b/var/spack/repos/builtin/packages/py-pyfr/package.py
index 7cbfe6ab71..9f81ef7597 100644
--- a/var/spack/repos/builtin/packages/py-pyfr/package.py
+++ b/var/spack/repos/builtin/packages/py-pyfr/package.py
@@ -41,7 +41,7 @@ class PyPyfr(PythonPackage, CudaPackage, ROCmPackage):
     depends_on("py-h5py@2.10:", type=("build", "run"))
     depends_on("py-mako@1.0.0:", type=("build", "run"))
     depends_on("py-mpi4py@3.1.0:", type=("build", "run"))
-    depends_on("py-numpy@1.20:+blas", type=("build", "run"))
+    depends_on("py-numpy@1.20:", type=("build", "run"))
     depends_on("py-platformdirs@2.2.0:", type=("build", "run"))
     depends_on("py-pytools@2016.2.1:", type=("build", "run"))
 
diff --git a/var/spack/repos/builtin/packages/py-pyzmq/package.py b/var/spack/repos/builtin/packages/py-pyzmq/package.py
index 4850dddc08..bf60b4be57 100644
--- a/var/spack/repos/builtin/packages/py-pyzmq/package.py
+++ b/var/spack/repos/builtin/packages/py-pyzmq/package.py
@@ -45,6 +45,9 @@ class PyPyzmq(PythonPackage):
 
     # pyproject.toml
     depends_on("py-setuptools", type="build")
+    # https://github.com/zeromq/pyzmq/issues/1278
+    # https://github.com/zeromq/pyzmq/pull/1317
+    depends_on("py-setuptools@:59", when="@17:18.0", type="build")
     depends_on("py-packaging", type="build")
 
     # setup.py
diff --git a/var/spack/repos/builtin/packages/py-scipy/package.py b/var/spack/repos/builtin/packages/py-scipy/package.py
index 4a07657d80..51f89f7d4c 100644
--- a/var/spack/repos/builtin/packages/py-scipy/package.py
+++ b/var/spack/repos/builtin/packages/py-scipy/package.py
@@ -3,16 +3,11 @@
 #
 # SPDX-License-Identifier: (Apache-2.0 OR MIT)
 
-import glob
-import os
-
 from spack.package import *
 
 
 class PyScipy(PythonPackage):
-    """SciPy (pronounced "Sigh Pie") is a Scientific Library for Python.
-    It provides many user-friendly and efficient numerical routines such
-    as routines for numerical integration and optimization."""
+    """Fundamental algorithms for scientific computing in Python."""
 
     homepage = "https://www.scipy.org/"
     pypi = "scipy/scipy-1.10.1.tar.gz"
@@ -20,7 +15,9 @@ class PyScipy(PythonPackage):
 
     maintainers("adamjstewart", "rgommers")
 
-    version("master", branch="master")
+    version("main", branch="main")
+    version("master", branch="master", deprecated=True)
+    version("1.11.3", sha256="bba4d955f54edd61899776bad459bf7326e14b9fa1c552181f0479cc60a568cd")
     version("1.11.2", sha256="b29318a5e39bd200ca4381d80b065cdf3076c7d7281c5e36569e99273867f61d")
     version("1.11.1", sha256="fb5b492fa035334fd249f0973cc79ecad8b09c604b42a127a677b45a9a3d4289")
     version("1.11.0", sha256="f9b0248cb9d08eead44cde47cbf6339f1e9aa0dfde28f5fb27950743e317bd5d")
@@ -65,22 +62,18 @@ class PyScipy(PythonPackage):
     depends_on("python@:3.8", when="@1.3.2:1.5.3", type=("build", "link", "run"))
     depends_on("python@:3.7", when="@1.1:1.3.1", type=("build", "link", "run"))
 
-    # TODO: remove once pip build supports BLAS/LAPACK specification
-    # https://github.com/mesonbuild/meson-python/pull/167
-    depends_on("py-build", when="@1.9:", type="build")
-
-    depends_on("py-meson-python@0.12.1:0.13", when="@1.11:", type="build")
-    depends_on("py-meson-python@0.11:0.12", when="@1.10.1:1.10", type="build")
-    depends_on("py-meson-python@0.11", when="@1.10.0", type="build")
-    depends_on("py-meson-python@0.9:", when="@1.9.2:1.9", type="build")
-    depends_on("py-meson-python@0.8.1:", when="@1.9.1", type="build")
-    depends_on("py-meson-python@0.7", when="@1.9.0", type="build")
-    depends_on("meson@0.62.2", when="@1.9.0:1.9.1", type="build")
+    depends_on("py-meson-python@0.12.1:", when="@1.11:", type="build")
+    depends_on("py-meson-python@0.11:", when="@1.10:", type="build")
+    depends_on("py-meson-python@0.9:", when="@1.9.2:", type="build")
+    depends_on("py-meson-python@0.8.1:", when="@1.9.1:", type="build")
+    depends_on("py-meson-python@0.7:", when="@1.9:", type="build")
+    depends_on("meson", when="@1.9.0:1.9.1", type="build")
     depends_on("py-cython@0.29.35:2", when="@1.11:", type="build")
     depends_on("py-cython@0.29.32:2", when="@1.9.2:", type="build")
     depends_on("py-cython@0.29.21:2", when="@1.9:", type="build")
     depends_on("py-cython@0.29.18:2", when="@1.7:", type="build")
-    depends_on("py-pybind11@2.10.4:2.10", when="@1.11:", type=("build", "link"))
+    depends_on("py-pybind11@2.10.4:2.11.0", when="@1.11.3:", type=("build", "link"))
+    depends_on("py-pybind11@2.10.4:2.10", when="@1.11.0:1.11.2", type=("build", "link"))
     depends_on("py-pybind11@2.10.1", when="@1.10", type=("build", "link"))
     depends_on("py-pybind11@2.4.3:2.10", when="@1.9.1:1.9", type=("build", "link"))
     depends_on("py-pybind11@2.4.3:2.9", when="@1.9.0", type=("build", "link"))
@@ -90,14 +83,11 @@ class PyScipy(PythonPackage):
     depends_on("py-pybind11@2.4.3:", when="@1.5:1.6.1", type=("build", "link"))
     depends_on("py-pybind11@2.4.0:", when="@1.4.1:1.4", type=("build", "link"))
     depends_on("py-pybind11@2.2.4:", when="@1.4.0", type=("build", "link"))
-    depends_on("py-pythran@0.12:0.13", when="@1.11:", type="build")
-    depends_on("py-pythran@0.12", when="@1.10", type="build")
-    depends_on("py-pythran@0.9.12:0.12", when="@1.9.2:1.9", type="build")
-    depends_on("py-pythran@0.9.12:0.11", when="@1.9.0:1.9.1", type="build")
-    depends_on("py-pythran@0.10", when="@1.8", type="build")
-    depends_on("py-pythran@0.9.12:0.9", when="@1.7.2:1.7", type="build")
-    depends_on("py-pythran@0.9.11", when="@1.7.0:1.7.1", type="build")
-    depends_on("py-wheel@:0.40", when="@1.11:", type="build")
+    depends_on("py-pythran@0.12:", when="@1.10:", type="build")
+    depends_on("py-pythran@0.10:", when="@1.8", type="build")
+    depends_on("py-pythran@0.9.12:", when="@1.7.2:", type="build")
+    depends_on("py-pythran@0.9.11:", when="@1.7:", type="build")
+    depends_on("py-wheel@:0.40", when="@1.11.0:1.11.2", type="build")
     depends_on("py-wheel@:0.38", when="@1.10", type="build")
     depends_on("py-wheel@:0.37", when="@:1.9", type="build")
     depends_on("pkgconfig", when="@1.9:", type="build")
@@ -105,43 +95,53 @@ class PyScipy(PythonPackage):
     depends_on("py-setuptools@:59", when="@1.8", type="build")
     depends_on("py-setuptools@:57", when="@1.7", type="build")
     depends_on("py-setuptools@:51.0.0", when="@1.6", type="build")
-    depends_on("py-numpy@1.21.6:1.27+blas+lapack", when="@1.11:", type=("build", "link", "run"))
-    depends_on("py-numpy@1.19.5:1.26+blas+lapack", when="@1.10", type=("build", "link", "run"))
-    depends_on("py-numpy@1.18.5:1.25+blas+lapack", when="@1.9", type=("build", "link", "run"))
-    depends_on("py-numpy@1.17.3:1.24+blas+lapack", when="@1.8", type=("build", "link", "run"))
-    depends_on(
-        "py-numpy@1.16.5:1.22+blas+lapack", when="@1.6.2:1.7", type=("build", "link", "run")
-    )
-    depends_on("py-numpy@1.16.5:+blas+lapack", when="@1.6:1.6.1", type=("build", "link", "run"))
-    depends_on("py-numpy@1.14.5:+blas+lapack", when="@1.5.0:1.5", type=("build", "link", "run"))
-    depends_on("py-numpy@1.13.3:+blas+lapack", when="@1.3:1.4", type=("build", "link", "run"))
-    depends_on("py-numpy@1.8.2:+blas+lapack", when="@:1.2", type=("build", "link", "run"))
+    depends_on("py-numpy@1.21.6:1.27", when="@1.11:", type=("build", "link", "run"))
+    depends_on("py-numpy@1.19.5:1.26", when="@1.10", type=("build", "link", "run"))
+    depends_on("py-numpy@1.18.5:1.25", when="@1.9", type=("build", "link", "run"))
+    depends_on("py-numpy@1.17.3:1.24", when="@1.8", type=("build", "link", "run"))
+    depends_on("py-numpy@1.16.5:1.22", when="@1.6:1.7", type=("build", "link", "run"))
+    depends_on("py-numpy@1.14.5:1.21", when="@1.5", type=("build", "link", "run"))
+    depends_on("py-numpy@1.13.3:1.21", when="@1.3:1.4", type=("build", "link", "run"))
+    depends_on("py-numpy@1.8.2:1.20", when="@:1.2", type=("build", "link", "run"))
     depends_on("py-pytest", type="test")
 
-    # NOTE: scipy should use the same BLAS/LAPACK as numpy.
-    # For scipy 1.8 and older, this is achieved by calling the set_blas_lapack()
-    # and setup_build_environment() from numpy in the scipy spec.
-    depends_on("blas")
-    depends_on("lapack")
+    # Required to use --config-settings
+    depends_on("py-pip@23.1:", when="@1.9:", type="build")
 
     # https://docs.scipy.org/doc/scipy/dev/toolchain.html#other-libraries
     depends_on("lapack@3.7.1:", when="@1.9:")
     depends_on("lapack@3.4.1:", when="@1.2:")
+    depends_on("lapack")
+    depends_on("blas")
 
+    # meson.build
     # https://docs.scipy.org/doc/scipy/dev/toolchain.html#compilers
-    conflicts("%gcc@:7", when="@1.10:")
-    conflicts("%gcc@:4.7", when="@:1.9")
-    conflicts("%apple-clang@:9", when="@1.10:")
-    conflicts("%msvc@:19.19", when="@1.10:")
+    conflicts("%gcc@:7", when="@1.10:", msg="SciPy requires GCC >= 8.0")
+    conflicts("%gcc@:4.7", when="@:1.9", msg="SciPy requires GCC >= 4.8")
+    conflicts(
+        "%msvc@:19.19",
+        when="@1.10:",
+        msg="SciPy requires at least vc142 (default with Visual Studio 2019) "
+        "when building with MSVC",
+    )
 
-    # https://github.com/scipy/scipy/pull/11324
-    conflicts("@1.4.0:1.4.1", when="target=ppc64le:")
+    # https://github.com/scipy/scipy/issues/19352
+    conflicts("^py-cython@3.0.3")
 
     # https://github.com/mesonbuild/meson/pull/10909#issuecomment-1282241479
     # Intel OneAPI ifx claims to support -fvisibility, but this does not work.
     # Meson adds this flag for all Python extensions which include Fortran code.
     conflicts("%oneapi@:2023.0", when="@1.9:")
 
+    # error: expected unqualified-id (exact compiler versions unknown)
+    conflicts("%apple-clang@15:", when="@:1.9")
+
+    # https://docs.scipy.org/doc//scipy-1.10.1/release.1.7.3.html
+    conflicts("platform=darwin target=aarch64:", when="@:1.7.2")
+
+    # https://github.com/scipy/scipy/pull/11324
+    conflicts("@1.4.0:1.4.1", when="target=ppc64le:")
+
     # https://github.com/scipy/scipy/issues/12860
     patch(
         "https://git.sagemath.org/sage.git/plain/build/pkgs/scipy/patches/extern_decls.patch?id=711fe05025795e44b84233e065d240859ccae5bd",
@@ -155,12 +155,6 @@ class PyScipy(PythonPackage):
     def archive_files(self):
         return [join_path(self.stage.source_path, "build", "meson-logs", "meson-log.txt")]
 
-    @run_before("install")
-    def set_blas_lapack(self):
-        # Pick up BLAS/LAPACK from numpy
-        if self.spec.satisfies("@:1.8"):
-            self.spec["py-numpy"].package.set_blas_lapack()
-
     @run_before("install")
     def set_fortran_compiler(self):
         if self.compiler.f77 is None or self.compiler.fc is None:
@@ -200,53 +194,27 @@ def setup_build_environment(self, env):
         if self.spec.satisfies("@:1.8"):
             self.spec["py-numpy"].package.setup_build_environment(env)
 
-    # TODO: remove once pip build supports BLAS/LAPACK specification
-    # https://github.com/mesonbuild/meson-python/pull/167
-    @when("@1.9:")
-    def install(self, spec, prefix):
-        blas = spec["blas"].libs.names[0]
-        lapack = spec["lapack"].libs.names[0]
-        if spec["blas"].name in ["intel-mkl", "intel-parallel-studio", "intel-oneapi-mkl"]:
-            blas = "mkl-dynamic-lp64-seq"
-        if spec["lapack"].name in ["intel-mkl", "intel-parallel-studio", "intel-oneapi-mkl"]:
-            lapack = "mkl-dynamic-lp64-seq"
-        if spec["blas"].name in ["blis", "amdblis"]:
-            blas = "blis"
-        if "armpl" in blas:
-            if "_mp" in blas:
-                blas = "armpl-dynamic-lp64-omp"
-            else:
-                blas = "armpl-dynamic-lp64-seq"
-        if "armpl" in lapack:
-            if "_mp" in lapack:
-                lapack = "armpl-dynamic-lp64-omp"
-            else:
-                lapack = "armpl-dynamic-lp64-seq"
+        # https://github.com/scipy/scipy/issues/19357
+        if self.spec.satisfies("%apple-clang@15:"):
+            env.append_flags("LDFLAGS", "-Wl,-ld_classic")
 
-        args = [
-            "setup",
-            "build",
-            "-Dblas=" + blas,
-            "-Dlapack=" + lapack,
-            "--prefix=" + join_path(os.getcwd(), "build-install"),
-            "-Ddebug=false",
-            "-Doptimization=2",
-        ]
-        meson = which("meson")
-        meson(*args)
-        args = [
-            "-m",
-            "build",
-            "--wheel",
-            "-Cbuilddir=build",
-            "--no-isolation",
-            "--skip-dependency-check",
-            "-Ccompile-args=-j%s" % make_jobs,
-            ".",
-        ]
-        python(*args)
-        args = std_pip_args + ["--prefix=" + prefix, glob.glob(join_path("dist", "scipy*.whl"))[0]]
-        pip(*args)
+    @when("@1.9:")
+    def config_settings(self, spec, prefix):
+        blas, lapack = self.spec["py-numpy"].package.blas_lapack_pkg_config()
+        return {
+            "builddir": "build",
+            "compile-args": f"-j{make_jobs}",
+            "setup-args": {
+                # http://scipy.github.io/devdocs/building/blas_lapack.html
+                "-Dblas": blas,
+                "-Dlapack": lapack,
+            },
+        }
+
+    @when("@:1.8")
+    @run_before("install")
+    def set_blas_lapack(self):
+        self.spec["py-numpy"].package.blas_lapack_site_cfg()
 
     @run_after("install")
     @on_package_attributes(run_tests=True)
diff --git a/var/spack/repos/builtin/packages/py-tomopy/package.py b/var/spack/repos/builtin/packages/py-tomopy/package.py
index b99e60ef91..59a1c0f1b3 100644
--- a/var/spack/repos/builtin/packages/py-tomopy/package.py
+++ b/var/spack/repos/builtin/packages/py-tomopy/package.py
@@ -34,7 +34,7 @@ class PyTomopy(PythonPackage):
     # Note: The module name of py-scikit-build is skbuild:
     depends_on("py-scikit-build", type=("build"))
     depends_on("py-scikit-image@0.17:", type=("build", "run"))
-    depends_on("py-numpy+blas", type=("build", "run"))
+    depends_on("py-numpy", type=("build", "run"))
     depends_on("py-pyfftw", type=("build", "run"), when="@1.0:1.9")
     depends_on("py-scipy", type=("build", "run"))
     depends_on("py-setuptools", type="build")