diff --git a/var/spack/repos/builtin/packages/py-anndata/package.py b/var/spack/repos/builtin/packages/py-anndata/package.py
new file mode 100644
index 0000000000..105cca9e4a
--- /dev/null
+++ b/var/spack/repos/builtin/packages/py-anndata/package.py
@@ -0,0 +1,28 @@
+# Copyright 2013-2022 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack.package import *
+
+
+class PyAnndata(PythonPackage):
+    """anndata is a Python package for handling annotated data matrices
+    in memory and on disk, positioned between pandas and xarray."""
+
+    homepage = "https://github.com/theislab/anndata"
+    pypi = "anndata/anndata-0.8.0.tar.gz"
+
+    version("0.8.0", sha256="94d2cc6f76c0317c0ac28564e3092b313b7ad19c737d66701961f3e620b9066e")
+
+    depends_on("python@3.7:", type=("build", "run"))
+    depends_on("py-setuptools-scm", type="build")
+    depends_on("py-flit-core@3.4:3", type="build")
+    depends_on("py-importlib-metadata@0.7:", type=("build", "run"), when="^python@:3.7")
+    depends_on("py-pandas@1.1.1:", type=("build", "run"))
+    depends_on("py-numpy@1.16.5:", type=("build", "run"))
+    depends_on("py-scipy@1.4.1:", type=("build", "run"))
+    depends_on("py-h5py@3:", type=("build", "run"))
+    depends_on("py-natsort", type=("build", "run"))
+    depends_on("py-packaging@20:", type=("build", "run"))
+    depends_on("py-typing-extensions", when="^python@:3.7", type=("build", "run"))