diff --git a/var/spack/repos/builtin/packages/py-ucsf-pyem/package.py b/var/spack/repos/builtin/packages/py-ucsf-pyem/package.py
new file mode 100644
index 0000000000..5e4e0b7f1f
--- /dev/null
+++ b/var/spack/repos/builtin/packages/py-ucsf-pyem/package.py
@@ -0,0 +1,38 @@
+# Copyright 2013-2021 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack import *
+
+
+class PyUcsfPyem(PythonPackage):
+    """UCSF pyem is a collection of Python modules and command-line
+    utilities for electron microscopy of biological samples."""
+
+    homepage = "https://github.com/asarnow/pyem"
+    git      = "https://github.com/asarnow/pyem.git"
+
+    maintainers = ['dorton21']
+
+    # Using commit since releases haven't been updated in 2 years
+    version('2021-04-07', commit='ed0527f98657d21d887357426b74e5240d477fae')
+
+    depends_on('py-setuptools', type='build')
+    depends_on('py-numpy@1.14:', type=('build', 'run'))
+    depends_on('py-scipy@1.2:', type=('build', 'run'))
+    depends_on('py-matplotlib@2.2:', type=('build', 'run'))
+    depends_on('py-future@0.15:', type=('build', 'run'))
+    depends_on('py-numba@0.41:', type=('build', 'run'))
+    depends_on('py-seaborn@0.9:', type=('build', 'run'))
+    depends_on('py-pandas@0.23.4:', type=('build', 'run'))
+    depends_on('py-pathos@0.2.1:', type=('build', 'run'))
+    depends_on('py-pyfftw@0.10:', type=('build', 'run'))
+    depends_on('py-healpy@1.11:', type=('build', 'run'))
+    depends_on('py-natsort@6.0:', type=('build', 'run'))
+
+    # Extracts files into bin for proper useage
+    @run_after('install')
+    def extraction(self):
+        mkdir(self.prefix.bin)
+        install('*.py', self.prefix.bin)