diff --git a/var/spack/repos/builtin/packages/libpciaccess/package.py b/var/spack/repos/builtin/packages/libpciaccess/package.py
index 14ee76f0b9..e8b9cb5621 100644
--- a/var/spack/repos/builtin/packages/libpciaccess/package.py
+++ b/var/spack/repos/builtin/packages/libpciaccess/package.py
@@ -18,3 +18,12 @@ class Libpciaccess(AutotoolsPackage):
     depends_on('libtool', type='build')
     depends_on('pkgconfig', type='build')
     depends_on('util-macros', type='build')
+
+    # A known issue exists when building with PGI as documented here:
+    # https://bugs.freedesktop.org/show_bug.cgi?id=94398
+    # https://www.pgroup.com/userforum/viewtopic.php?f=4&t=5126
+    # https://gitlab.freedesktop.org/xorg/lib/libpciaccess/issues/7
+    #
+    # When the ability to use dependencies built by another compiler, using a
+    # libpciaccess built by gcc should be usable by PGI builds.
+    conflicts('%pgi')