diff --git a/var/spack/repos/builtin/packages/amrex/package.py b/var/spack/repos/builtin/packages/amrex/package.py
index d3414e575e..8c077e7921 100644
--- a/var/spack/repos/builtin/packages/amrex/package.py
+++ b/var/spack/repos/builtin/packages/amrex/package.py
@@ -6,7 +6,7 @@
 from spack import *
 
 
-class Amrex(CMakePackage, CudaPackage):
+class Amrex(CMakePackage, CudaPackage, ROCmPackage):
     """AMReX is a publicly available software framework designed
     for building massively parallel block- structured adaptive
     mesh refinement (AMR) applications."""
@@ -81,6 +81,7 @@ class Amrex(CMakePackage, CudaPackage):
     depends_on('cmake@3.14:', type='build', when='@19.04:')
     # cmake @3.17: is necessary to handle cuda @11: correctly
     depends_on('cmake@3.17:', type='build', when='^cuda @11:')
+    depends_on('rocrand', type='build', when='+rocm')
     conflicts('%apple-clang')
     conflicts('%clang')
 
@@ -113,6 +114,8 @@ class Amrex(CMakePackage, CudaPackage):
     conflicts('cuda_arch=21', when='+cuda', msg='AMReX only supports compute capabilities >= 3.5')
     conflicts('cuda_arch=30', when='+cuda', msg='AMReX only supports compute capabilities >= 3.5')
     conflicts('cuda_arch=32', when='+cuda', msg='AMReX only supports compute capabilities >= 3.5')
+    conflicts('+rocm', when='@:20.11', msg='AMReX HIP support needs AMReX newer than version 20.11')
+    conflicts('+cuda', when='+rocm', msg='CUDA and HIP support are exclusive')
 
     def url_for_version(self, version):
         if version >= Version('20.05'):
@@ -200,4 +203,10 @@ def cmake_args(self):
             cuda_arch = self.spec.variants['cuda_arch'].value
             args.append('-DCUDA_ARCH=' + self.get_cuda_arch_string(cuda_arch))
 
+        if '+rocm' in self.spec:
+            args.append('-DCMAKE_CXX_COMPILER={0}'.format(self.spec['hip'].hipcc))
+            args.append('-DAMReX_GPU_BACKEND=HIP')
+            targets = self.spec.variants['amdgpu_target'].value
+            args.append('-DAMReX_AMD_ARCH=' + ';'.join(str(x) for x in targets))
+
         return args