diff --git a/var/spack/repos/builtin/packages/py-gffutils/package.py b/var/spack/repos/builtin/packages/py-gffutils/package.py
new file mode 100644
index 0000000000..8854e47df6
--- /dev/null
+++ b/var/spack/repos/builtin/packages/py-gffutils/package.py
@@ -0,0 +1,30 @@
+# Copyright 2013-2021 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack import *
+
+
+class PyGffutils(PythonPackage):
+    """GFF and GTF file manipulation and interconversion
+
+    gffutils is a Python package for working with and manipulating the GFF and
+    GTF format files typically used for genomic annotations. Files are loaded
+    into a sqlite3 database, allowing much more complex manipulation of
+    hierarchical features (e.g., genes, transcripts, and exons) than is
+    possible with plain-text methods alone."""
+
+    homepage = "https://github.com/daler/gffutils"
+    pypi     = "gffutils/gffutils-0.10.1.tar.gz"
+
+    maintainers = ['dorton21']
+
+    version('0.10.1', sha256='a8fc39006d7aa353147238160640e2210b168f7849cb99896be3fc9441e351cb')
+
+    depends_on('py-setuptools', type='build')
+    depends_on('py-pyfaidx@0.5.5.2:', type=('build', 'run'))
+    depends_on('py-six@1.12.0:', type=('build', 'run'))
+    depends_on('py-argh@0.26.2:', type=('build', 'run'))
+    depends_on('py-argcomplete@1.9.4:', type=('build', 'run'))
+    depends_on('py-simplejson', type=('build', 'run'))