diff --git a/var/spack/repos/builtin/packages/qt/package.py b/var/spack/repos/builtin/packages/qt/package.py
index 50940d3d52..3298d9d58c 100644
--- a/var/spack/repos/builtin/packages/qt/package.py
+++ b/var/spack/repos/builtin/packages/qt/package.py
@@ -154,6 +154,7 @@ class Qt(Package):
 
     conflicts('%gcc@10:', when='@5.9:5.12.6 +opengl')
     conflicts('%gcc@11:', when='@5.8')
+    conflicts('%apple-clang@13:', when='@:5.13')
 
     # Build-only dependencies
     depends_on("pkgconfig", type='build')