diff --git a/var/spack/repos/builtin/packages/py-quast/package.py b/var/spack/repos/builtin/packages/py-quast/package.py
index 7ba99767b6..a574185b0b 100644
--- a/var/spack/repos/builtin/packages/py-quast/package.py
+++ b/var/spack/repos/builtin/packages/py-quast/package.py
@@ -11,11 +11,15 @@ class PyQuast(PythonPackage):
     """Quality Assessment Tool for Genome Assemblies"""
 
     homepage = "https://cab.spbu.ru/software/quast"
-    url = "https://github.com/ablab/quast/archive/quast_4.6.1.tar.gz"
+    pypi = "quast/quast-5.2.0.tar.gz"
 
-    version("4.6.3", sha256="d7f5e670563d17d683f6df057086f7b816b6a088266c6270f7114a1406aaab63")
-    version("4.6.1", sha256="a8071188545710e5c0806eac612daaabde9f730819df2c44be3ffa9317b76a58")
-    version("4.6.0", sha256="6bee86654b457a981718a19acacffca6a3e74f30997ad06162a70fd2a181ca2e")
+    version("5.2.0", sha256="23649fbd93253c6da982c0b67d719f9262461deecdc6dffbd690b75dfd790ad7")
+    version("5.0.2", sha256="cdb8f83e20cc38f218ff7172b454280fcb1c7e2dff74e1f8618cacc53d46b48e")
+    version("5.0.1", sha256="b1e4443b6598b01faaefddfc0f06fb270414ed4bdaffd0ad9aa420bc0d07d8ad")
+    version("5.0.0", sha256="46bba247c7f92c2ccaca8c0abeab2a8d40a257a0cbe2fa0a4ffa981ca0267526")
+    version("4.6.3", sha256="f9267e5deadf20cfe67731a42e775e7ef1d0850927a2a76c4b3d49bc77b1fab5")
+    version("4.6.1", sha256="7ace5bebebe9d2a70ad45e5339f998bd651c1c6b9025f7a3b51f44c87ea5bae0")
+    version("4.6.0", sha256="3a7ee7a2abfeb0541b299b67f263ba95f9743f8809ddf5dfaca9c3c8f9b6a215")
 
     depends_on("boost@1.56.0")
 
@@ -23,10 +27,12 @@ class PyQuast(PythonPackage):
     # for instance depends_on('boost +filesystem')
     # See https://github.com/spack/spack/pull/22303 for reference
     depends_on(Boost.with_default_variants)
-    depends_on("perl@5.6.0:")
-    depends_on("python@2.5:,3.3:")
+    depends_on("perl@5.6.0:", type=("build", "run"))
+    depends_on("python@2.5:,3.3:", type=("build", "run"))
     depends_on("py-setuptools", type="build")
     depends_on("py-matplotlib", type=("build", "run"))
+    depends_on("py-joblib", type=("build", "run"))
+    depends_on("py-simplejson", type=("build", "run"))
     depends_on("java", type=("build", "run"))
     depends_on("perl-time-hires", type=("build", "run"))
     depends_on("gnuplot", type=("build", "run"))