diff --git a/lib/spack/spack/main.py b/lib/spack/spack/main.py
index 00131114f6..8d4e73bc65 100644
--- a/lib/spack/spack/main.py
+++ b/lib/spack/spack/main.py
@@ -855,6 +855,23 @@ def shell_set(var, value):
             shell_set("_sp_module_prefix", "not_installed")
 
 
+def restore_macos_dyld_vars():
+    """
+    Spack mutates DYLD_* variables in `spack load` and `spack env activate`.
+    Unlike Linux, macOS SIP clears these variables in new processes, meaning
+    that os.environ["DYLD_*"] in our Python process is not the same as the user's
+    shell. Therefore, we store the user's DYLD_* variables in SPACK_DYLD_* and
+    restore them here.
+    """
+    if not sys.platform == "darwin":
+        return
+
+    for dyld_var in ("DYLD_LIBRARY_PATH", "DYLD_FALLBACK_LIBRARY_PATH"):
+        stored_var_name = f"SPACK_{dyld_var}"
+        if stored_var_name in os.environ:
+            os.environ[dyld_var] = os.environ[stored_var_name]
+
+
 def _main(argv=None):
     """Logic for the main entry point for the Spack command.
 
@@ -887,18 +904,6 @@ def _main(argv=None):
     parser.add_argument("command", nargs=argparse.REMAINDER)
     args, unknown = parser.parse_known_args(argv)
 
-    # Recover stored LD_LIBRARY_PATH variables from spack shell function
-    # This is necessary because MacOS System Integrity Protection clears
-    # (DY?)LD_LIBRARY_PATH variables on process start.
-    # Spack clears these variables before building and installing packages,
-    # but needs to know the prior state for commands like `spack load` and
-    # `spack env activate that modify the user environment.
-    recovered_vars = ("LD_LIBRARY_PATH", "DYLD_LIBRARY_PATH", "DYLD_FALLBACK_LIBRARY_PATH")
-    for var in recovered_vars:
-        stored_var_name = "SPACK_%s" % var
-        if stored_var_name in os.environ:
-            os.environ[var] = os.environ[stored_var_name]
-
     # Just print help and exit if run with no arguments at all
     no_args = (len(sys.argv) == 1) if argv is None else (len(argv) == 0)
     if no_args:
@@ -921,6 +926,9 @@ def _main(argv=None):
     # scopes, then environment configuration here.
     # ------------------------------------------------------------------------
 
+    # Make spack load / env activate work on macOS
+    restore_macos_dyld_vars()
+
     # make spack.config aware of any command line configuration scopes
     if args.config_scopes:
         spack.config.command_line_scopes = args.config_scopes
diff --git a/share/spack/csh/spack.csh b/share/spack/csh/spack.csh
index c9f6242a3e..e344d589f8 100644
--- a/share/spack/csh/spack.csh
+++ b/share/spack/csh/spack.csh
@@ -27,12 +27,9 @@
 # avoids the need to come up with a user-friendly naming scheme for
 # spack module files.
 ########################################################################
-# Store LD_LIBRARY_PATH variables from spack shell function
+# Store DYLD_* variables from spack shell function
 # This is necessary because MacOS System Integrity Protection clears
 # variables that affect dyld on process start.
-if ( ${?LD_LIBRARY_PATH} ) then
-    setenv SPACK_LD_LIBRARY_PATH $LD_LIBRARY_PATH
-endif
 if ( ${?DYLD_LIBRARY_PATH} ) then
     setenv SPACK_DYLD_LIBRARY_PATH $DYLD_LIBRARY_PATH
 endif
diff --git a/share/spack/setup-env.sh b/share/spack/setup-env.sh
index d3a97d9af6..7d4554359f 100755
--- a/share/spack/setup-env.sh
+++ b/share/spack/setup-env.sh
@@ -47,10 +47,10 @@ export _sp_initializing=true
 
 
 _spack_shell_wrapper() {
-    # Store LD_LIBRARY_PATH variables from spack shell function
+    # Store DYLD_* variables from spack shell function
     # This is necessary because MacOS System Integrity Protection clears
     # variables that affect dyld on process start.
-    for var in LD_LIBRARY_PATH DYLD_LIBRARY_PATH DYLD_FALLBACK_LIBRARY_PATH; do
+    for var in DYLD_LIBRARY_PATH DYLD_FALLBACK_LIBRARY_PATH; do
         eval "if [ -n \"\${${var}-}\" ]; then export SPACK_$var=\${${var}}; fi"
     done